李越中

电话：0531-88564288 传真： E-Mail：lilab@sdu.edu.cn

教育背景
         起止时间              毕业院校          专业
博士  1990.9-1993.7           山东大学         微生物学
硕士  1987.9-1990.7          山东农业大学      真菌学
本科  1983.9-1987.7          山东大学          微生物学

工作经历
 起止时间                单位名称            专业技术职务
1993.7-1995.8   中科院沈阳应用生态研究所     博士后
1995.9至今      山东大学生命学院             副教授(1995年), 教授 (2000年)

科研方向
1.粘细菌多样性、生态与进化
2.粘细菌细胞群体行为及进化适应
3.抗肿瘤化合物埃博霉素及其生物工程改造

主持课题

1.2008-2012  粘细菌及其细胞行为社会性的进化适应、分子机制及其利用  国家杰出青年基金
2.2012-2016 粘细菌细胞群体行为对海洋生境适应的进化基因组分析       国家自然基金重点项目
3.2013-2016  能源与医药产品模块化设计合成                         863子课题

代表性论文

1.Wang Y, Li X, Zhang W, Zhou X, Li YZ*. groEL2, but not groEL1, is required for the biosynthesis of the secondary metabolite myxovirescin in Myxococcusxanthus DK1622. Microbiology. 2014. 160, 488-495.
2.Shu-guang Li, Lin Zhao, Kui Han, Peng-fei Li, Zhi-feng Li, Hong Liu, Zhi-hong Liu, Yue-zhong Li*. Diversity of epothilone producers among Sorangium strains in producer-positive soil habitats. MicrobBiotechnol, 2014, 7(2), 130-141.
3.Kui Han, Zhi-feng Li, Ran Peng, Li-ping Zhu, Tao Zhou, Lu-guang Wang, Shu-guang Li, Xiao-bo Zhang, Wei Hu, Zhi-hong Wu, Nan Qin and Yue-zhong Li*. Extraordinary expansion of a Sorangiumcellulosum genome from an alkaline milieu.Sci Rep, 2013, 3, 2101.
4.Peng-fei Li, Shu-guang Li, Zhi-feng Li, Lin Zhao, Ting Wang, Hong-wei Pan, Hong Liu, Zhi-hong Wu andYue-zhong Li*. Co-cultivation of Sorangiumcellulosum strains affects cellular growth and biosynthesis of secondary metabolite epothilones. FEMS MicrobiolEcol, 2013, 85, 358-368.
5.WJ Han, JY Gu, HH Liu, FC Li, ZH Wu, YZ Li*. An extra peptide within the catalytic module of a beta-agarase affects the agarose degradation pattern. J BiolChem, 2013, 288(13): 9519–9531.
6.Y Wang, WY Zhang, Z Zhang, J Li, ZF Li, ZG Tan, TT Zhang, ZH Wu, H Liu, YZ Li*. Mechanisms involved in the functional divergence of duplicated GroELchaperonins in Myxococcusxanthus DK1622. PLoS Genet, 2013, 9(2): e1003306.
7.J Feng, XJ Chen, X Sun, N Wang, YZ Li*.Characterization of the replication origin of the myxobacterial self-replicative plasmid pMF1. Plasmid, 68(2012): 105–112.
8.DM Jiang, C Kato, XW Zhou, ZH Wu, T Sato, YZ Li*. Phylogeographic separation of marine and soil myxobacteria at high levels of classification. The ISME Journal, 2010, 4: 1520-1530.
9.HW Pan, ZG Tan, H Liu, ZF Li, CY Zhang, CY Li, J Li, YZ Li*. Hdsp, a horizontally transferred gene required for social behavior and halotolerance in salt-tolerant Myxococcusfulvus HW-1. The ISME Journal, 2010, 4: 1282-1289.
10.J Li, Y Wang, CY Zhang, WY Zhang, DM Jiang, ZH Wu, H Liu, YZ Li*. Myxococcusxanthus viability depends on GroEL supplied by either of two genes, but the paralogs have different functions during heat shock, predation, and development. J Bacteriol, 2010, 192(7): 1875-1881.

专利  
1.一株耐碱纤维堆囊菌及其在制备埃博霉素中的应用，授权时间：2010.10，专利号：ZL 2008 1 0157515.7。
2.埃博霉素苷类化合物和以其为活性成分的组合物及其应用，授权时间：2014.01，日本专利特许第5462268号。