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山东大学国家糖工程技术研究中心教授、博士生导师。1999年与2002年分别在中国海洋大学食品科学与工程系和中国海洋大学海洋药物与食品研究所获得理学学士和工学硕士学位。2002年赴美国爱荷华大学(University of Iowa)药学院攻读博士学位;2003年随导师转入美国仁斯利尔理工学院(Rensselaer Polytechnic Institute)化学与化学生物系,2006年获得博士学位。2005年曾在美国新泽西葛兰素史克公司(GlaxoSmithKline)担任实习顾问。2007年起在美国芝加哥雅培公司(Abbott Laboratories)担任资深科学家。主要研究方向为(1)生物质谱技术在大分子结构研究中的应用;(2)重大疾病的蛋白组学和糖组学;诊断标志物及新药靶点研究;(3)蛋白药物、糖药物和中药的结构表征和代谢动力学等。

主持项目:

1、国家自然科学基金青年基金癌症生物标志物糖基化及影响抗体亲和的质谱研究”(31000367)

2、教育部博士点基金糖链结构信息库和糖链质谱数据库的构建20100131120071);

3、山东省自然科学基金肝素多糖结构的质谱分析研究ZR2010CM041);

4、济南市高校自主创新计划“Biomarker糖基化异常分析及相关肿瘤的免疫诊断试剂的研究开发201102022);

5、山东大学自主创新基金质谱分析药用糖胺聚糖细微结构研究2010TB010);

6、横向课题低分子肝素寡糖序列及糖片断研究

参与项目:

1、国家973计划项目肿瘤的糖化学生物学前沿研究”(2012CB822100)课题2“糖链探针的生物合成研究,学术骨干

2重大新药创制科技重大专项十二五计划第二批课题糖疫苗及相关技术体系的建立与研究2012ZX09502-001-005),学术骨干

代表论文:

1.J. P. Skinner, L. Chi, P. F. Ozeata, C. S. Ramsay, R. L. O'Hara, B. B. Calfin, S. Y. Tetin,  Introduction of the mass spread function for characterization of protein conjugates, Analytical Chemistry, 2012, 84, 1172-1177.

2.Y. Wang, Z. Lu, F. Feng, W. Zhu, H. Guang, J. Liu, W. He, L. Chi*, Z. Li, H. Yu, Molecular cloning and characterization of novel cathelicidin-derived myeloid antimicrobial peptide from Phasianuscolchicus, Developmental and Comparative Immunology, 2011, 35, 314-322. (Corresponding author)

3.L. Chi, J. Wolff, T. Laremore, O. Restaino, J. Xie, C. Schiraldi, T. Toida, J. Amster, R. J. Linhardt, Structural analysis of bikunin glycosaminoglycan, Journal of the American Chemical Society, 2008, 130, 2617-2625.

4.T. Vorup-Jensen,L. Chi, L. C. Gjelstrup, U. B. Jensen, C. A. Jewett, C. Xie, M. Shimaoka, R. J. Linhardt, T.A. Springer, Binding between the integrin alphaXbeta2 (CD 11c/CD l8) and heparin,Journal of Biological Chemistry, 2007, 282, 30869-30877.5.J. Wolff, L. Chi, R. J. Linhardt, J. Amster, Distinguishing glucuronic from iduronic acid in glycosaminoglycan tetrasaccharides by using electron detachment dissociation, Analytical Chemistry, 2007, 79, 2015-2022.

6.J. Wolff, J. Amster, L. Chi, R. J. Linhardt, Electron detachment dissociation of fragmentation of glycosaminoglycan tetrasaccharides, Journal of the American Society for Mass Spectrometry, 2007, 18, 234-244.

7.J. C. Krupa, D. Shaya, L. Chi, R. J. Linhardt, M. Cygler, S. G. Withers, J. S. Mort, Quantitative continuous assay for hyaluronan synthase, Analytical Biochemistry, 2007, 361, 218-255.

8.S.A. Mousa, F. Zhang, A. Ajada, S. Chaturvedi, M. Takieddin, H. Zhang, L. Chi, M. C. Castelli, K. Friedman, M. M. Goldberg, R. J. Linhardt, Pharmacokinetics and pharmacodynamics of oral heparin solid dosage form in healthy human subjects, The Journal of Clinical Pharmacology, 2007, 47, 1508-1520.

9.L. Chi, E. M. Munoz, H. S. Choi, Y. W. Ha, Y. S. Kim, T. Toida, R. J. Linhardt, Preparation and structural determination of large oligosaccharides derived from acharan sulfate, Carbohydrate Research, 2006, 341, 864-869.

10.F. Zhang, P. Sun, E. M. Munoz, L. Chi, S. Sakai, T. Toida, R. J. Linhardt, Microscale isolation and analysis of heparin from plasma using an anion exchange spin column, Analytical Biochemistry, 2006, 353, 284-286.

11.L. Chi, J. Amster, R. J. Linhardt, Mass spectrometry for the analysis of highly charged sulfated carbohydrates, Current Analytical Chemistry, 2005, 1, 223-240.

12.M. Warda, E. M. Gouda, T. Toida, L. Chi, R. J. Linhardt, Isolation and characterization of raw heparin from dromedary intestine: evaluation of a new source of pharmaceutical heparin, Comparative Biochemistry and Physiology Part C, 2003, 136C, 357-365.

 

 

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