孔健
电话:0531-88362318 传真: E-Mail:kongjian@sdu.edu.cn
教育背景
起止时间 毕业院校 专业
博士 1997.9-2000.6 山东大学 微生物学
硕士 1988.9-1992.6 山东大学 微生物学
本科 1982.9-1986.6 山东大学 微生物学
1999.4-2001.7 丹麦皇家畜牧与农业大学 乳品科学
工作经历
起止时间 单位名称 专业技术职务
2002.9--至今 山东大学 博士生导师
2001.9--至今 山东大学 教授
1997.9-2001.9 山东大学 副教授
1992.9-1997.9 山东大学 讲师
1986.7-1992.9 山东大学 助教
科研方向
1.乳酸菌生理遗传及其分子生物学
2.乳酸菌噬菌体多样性及其抗性机制
3.益生菌与肠道健康
主持课题
1. 2012.1--2016.12 畜禽肠道健康新产品及评价技术 国家科技支撑计划 (2012BAD39B01)
2. 2012.1--2016.12 乳杆菌噬菌体裂解素和穿孔素功能解析 国家自然基金(31271905)
3. 2011.1--2015.12 乳酸菌代谢工程及调控技术研究国家863 (2011AA100902)
4. 2011.1--2013.12 人工启动子库的建立及其对乳酸乳球菌丙酮酸代谢途径的优化 国家自然基金(31070091)
5. 2011.1--2013.12 乳酸菌菌种资源库的建立及优良乳品发酵剂的高密度发酵技术 省科技计划(20100131110035)
研究成果
1. Zhilan Sun,Jian Kong*, Shumin Hu, Wentao Kong, Wenwei Lu, Wei Liu. Characterization of a S-layer protein from Lactobacillus crispatus K313 and the domains responsible for binding to cell wall and adherence to collagen. ApplMicrobiolBiotechnol, 2013. 97:1941–1952. (IF 3.425)
2. Longyun Fu,Jian Kong*, Zhilan Sun,, Li Zhang, Xia Zhang, TingtingGuo. Enhancing the oxidative resistance of yoghurt starter bacteria with heterologous catalase expression in Streptococcus thermophilus. International Dairy Journal 30 (2013) 68-72. (IF 2.401)
3. Yi Xu, Jian Kong* and Wentao Kong. Improved membrane protein expression in Lactococcuslactis by fusion to Mistic. Microbiology (2013), 159, 1002–1009.(IF 3.061)
4. Wenwei Lu,Jian Kong*, Wentao Kong.Construction and Application of a Food-Grade Expression System for Lactococcuslactis.Molecular biotechnology. 2013, 54:170–176•(IF 2.171)
5. Zhilan Sun, Lihua Huang,Jian Kong*, Shumin Hu, Xiaowei Zhang, Wentao Kong. In vitro evaluation of Lactobacillus crispatus K313 and K243: High-adhesion activity and anti-inflammatory effect on Salmonella braenderup infected intestinal epithelial cell. Veterinary Microbiology. 2012, 159 :212–220. (IF 3.256)
6. TingtingGuo, Jian Kong*, Li Zhang, Chenchen Zhang, Shumin Hu.Fine Tuning of the Lactate and Diacetyl Production through Promoter Engineering in Lactococcuslactis.PLoS ONE. 2012, 7(4):1-10. (IF 4.411)
7. Hu S, Kong J*, Sun Z, Han L, Kong W, Yang P. Heterologous Protein Display on the Cell Surface of Lactic Acid Bacteria Mediated by the S-Layer Protein. Microb Cell Fact. 2011,28;10(1):86. (IF 4.54)
8. Xiuhong Zhang, Shaohua Wang, TingtingGuo, Jian Kong*. Genome analysis of Lactobacillus fermentum temperate bacteriophage ФPYB5. International Journal of Food Microbiology. 2011, 144: 400–405. (IF 3.143)
9. Hu SM, Kong J*, Kong WT, Ji M. Characterization of a Novel LysM Domain from Lactobacillus fermentum Bacteriophage Endolysin and Its Use as an Anchor to Display Heterologous Proteins on the Surface of Lactic Acid Bacteria. Appl Environ Microbiol, 2010,76(8):1752-1760 (3.68)
10. Wang SH, Kong J*, Gao C. Isolation and characterization of a novel virulent phage (phiLdb) of Lactobacillus delbrueckii. International Journal of Food Microbiology. 2010, 137 : 22–2. (IF 3.143)
专利
1. 绿色巴夫藻C20多不饱和脂肪酸延伸酶的核苷酸序列及应用, 2009.10, ZL20071007100152165